Beijing Guangming Chinese Medicine Institute for Burns, Wounds and Ulcers, the main body of MEBO group, was officially registered as a science and technology enterprise in 1990 and has had now approximately 100 researchers and technicians, 30% of whom acquire senior titles. In addition to a central laboratory for science research, the institute has set up a pilot laboratory for developing new products and several laboratories on basic theory research pursuant to the comprehensive system of life science proposed by Professor Rongxiang Xu, such as pharmaceutical laboratory, molecular biology laboratory, microbiology and micro-anatomy laboratory. Moreover, there is a national medical network involving 65 medical centers and 4500 hospitals served as the base for clinic research.

Great efforts are put into the basic theory research since it gives the evidence of actual strength of research system. At present, jointed by distinguished experts from universities and institutes across the country, a network involving five research bases has been founded with the group's laboratories as the main body. The following is the significant achievements acquired in the past ten years on the basis of medical theory for burns, wounds and ulcers proposed by Professor Xu Rongxiang.

1. Accomplished the forefront human life medical research on skin regeneration by means of skin "clone" and successfully applied it in treating extensive full-thickness burns;
2. Initially explored new ways of anti-bacteria and anti-infection without killing bacteria by adjusting the ecology and structure of microbes;
3. On the basis of Moist Exposed Burn Therapy (MEBT) of regenerating and repairing burn tissues, established a new theory complying with life regularity and proposed a new conception and methodology on life medical science;
4. Discovered the principle of metabolism and substitution for the second and third generations cells in human life activities, fulfilled the research on the metabolism adjusting of normal physiological state so as to return to a younger state for normal skin cells.

The ultimate mission of the basic theory research is to create a better life for human being and to transform its breakthroughs into group's strong commercial presence, the research system is making every effort to carry out clinical research and develop advanced technology and products to respond the markets.

The breakthroughs and new concept pursuant to life regularity have witnessed the birth of application technology ----- Moist Exposed Burn Therapy (MEBT) to create a physiologically moist environment for repairing and regenerating of burn tissues as well as the development of coordinated medicine ---- Moist Exposed Burn Ointment (MEBO).

The innovation of nutrition foods for skin derived from the natural plant active tissues to make the state of normal cells younger incorporates the breakthrough on researching skin cell metabolism and substitution principle.

The newly discovered regularity of nutrition absorption and clock of human body has been found in applications of full-nutrition and full-absorption food with the minimum consumption.

The research system, based on the basic research on life medical science, has established three advanced technologies, specifically the technology of skin repairing and regenerating on the basis of burn and ulcer therapy, the technology in skincare using natural active tissues to develop skin nutrition and a serial of products, the technology of life nutrition to produce high-efficient, high-energy and high-nutrition food.

Pharmaceutical Research and Development

The Pharmaceutical Research and Development System plays a crucial role in turning theoretical breakthrough into products and academic achievements into applied technique. Three research and development systems including Pharmaceutical system, Beauty and Skin Care Products one, Food and Nutrition Elements one act as the mainstays to realize the Group's high-tech development strategy. Among them, the priority is given to Pharmaceutical Research and Development System keeps.

Moist Exposed Burn Ointment (MEBO) is the first Chinese medicine acquiring U.S. patent. It is a fat-soluble medical ointment with a special frame structure, containing active ingredients with functions of anti-inflammatory, anti-ulcer forming and anti-spasm, a base made of full nutrition for the recovery of skin and natural substances for accelerating the liquefaction and discharge of the necrotic tissues. The specially designed MEBO base and the ingredients create a physiologically moist environment for the regeneration and repair of the wounds and accelerate the liquefaction of necrotic tissue. Meantime, the frame structure dosage in which the oil of medicine is contained in the special form, shows a function of skin respiring, which not only successfully isolates the wound from external environment, but also maintains the fluent liquefaction and discharge of excretions and constant medicine supply. Characterized with the combination of special dosage form and special base, MEBO claims as the only medicine which can successfully solve the four major difficulties in treating burns so far---- pain, infection, progressive necrosis and deep II degree burns healed with scars. It has become the desired medicine in treating burn patients over 90% TBSA. The satisfactory clinical therapeutic effects won MEBO a certificate of National New Product. So far, MEBO has been officially registered in and imported to many countries such as South Korea, Thailand, Syria, UAE, Egypt and Saudi Arabia. The application for FDA botanic drug's approval in USA is in the course of procedure.

Thin layer Chromatograph of one of ingredients of burn ointment

Based upon the frame dosage form of MEBO ointment, we have successively developed series products dealing with ulcers in body surface and mucous ulcers. According to the clinical results, MEBO is evaluated as the 100% effective drug for some complicated ulcers such as diabetic extremities ulcers, radiological ulcers, bedsore, chronic venous ulcers in lower extremity and cervical erosion. Following the presence of MEBO ointments with frame dosage form, a range of MEBO creams made from MEBO base and fresh botanic tissue fluid have been available. Experiments have shown five main functions of the products, namely, repairing the damaged skin to be in a normal physiological state; thinning the cornified layer of skin to ease the osmosis of the active ingredients so as to improve bioavailability; promoting the cell in basal and spinous layer to grow more vigorous so as to enhance the immunity of the skin in affected area; accelerating the metabolism of fatty acid to strengthen the ability of anti-infection; promoting fungus to vary morphologically so as to reduce bacterial toxicity to keep skin in a normal physiological state. Being used as the base of medicines for common skin disease, together with the ingredients of anti-inflammatory and anti-fungus, it can effectively accelerate the recovery of the affected skin, enhance the body's immunity against pathogen, prevent the reoccurrence of diseases such as tinea corporis, tinea cruris, etc. MEBO Dermhealth Cream, the first medicine with MEBO cream base, has been put into the market and highly evaluated by clinical doctors and patients.

Beauty and Skin Care Products Research and Development

On the basis of Professor Rongxiang Xu's scientific breakthroughs in the discovery of the regularity of cell metabolism and skin regeneration, MEBO Group has developed a new range of MEBO skin care products made of natural active plant constituents, keeping skin cell in the normal physiological state has been developed. They are designed completely different from the conventional cosmetics in conception, breaking the model that cosmetics are made with chemical agents. It is Professor Xu's another breakthrough in skin care field following his revolutionary burn therapy.

The study shows that the human skin keeps changing according to a certain rule from the very beginning of birth. The first generation of skin is from birth till 20 years old, the second starting at 20-year-old when skin grows mature till 30-year-old and from 60-year-old it turning to age. Such process is so-called generation alteration of cell and the process for male is 5 years later than that for female in the stage since the second generation. If no external factors interfered, the skin normally grows conforming to the actual age. When there are external factors involved, however, or improper use of cosmetics, a big margin shows up between appeared age and actual age, i.e, much older than it should be. This is resulted from some unexpected changes due to external interference when skin is undergoing normal generation alteration and physiological metabolism. Aiming at avoiding such unexpected changes of skin, MEBO range skincare products are developed, utilizing purely natural plant tissue as main ingredients combined with MEBO base which is characterized to promote physiological metabolism and adjustment.

When comes the second generation, skin begins to age due to the inadequate nutrition supply and harmful irritation from environment. MEBO Full Nutrition Cream, being marketed soon, is specially designed for the skin at this stage. Made with the active ingredients extracted from natural plants, it provides skin with full nutrition and enhances the discretion of sebaceous cells so as to recover the normal physiological metabolism to keep skin healthy and young.

MEBO Block Cream is designed for those who are used to powder foundation and colored cosmetics made of the ground ore powder. Though the powder is finely ground, it is actually in a structure of triangle and diamond, which may directly stimulate skin cells, resulting in skin damage and aging. While the colored cosmetics are a kind of chemical dye and their application for long time must lead to chemical damage to skin. MEBO Block Cream, however, is in a special dosage of frame structure providing nourish to skin. Prior to the application of powder foundation and colored cosmetics, smear MEBO cream on the face to form a block layer, which can protect the skin from the direct contact with triangle or diamond particles so as to avoid the damage to skin while nourish the skin at the same time.

Since 1995, as the plentiful fruits of the research have been achieved on research and development of beauty and skincare products, a series of products are gradually being put into the market, namely, MEBO Dermhealth Cream, MEBO SCAReducer, MEBO Soften-beauty Cream, MEBO Cleaning Cream, MEBO Itching Reliever. These products are popular in domestic market and also exported to international markets including USA and UK. At present, there are more new products with brand name of MEBO under research.

Food and Nutrition Research and Development

Among three life technique systems of MEBO Group, Research and Development System on food & essential nutritional factors is a major research direction of the Group in the future. To be more healthy and more energetic in 21th century, it becomes a mission for the scientific researchers to develop the best full nutrition food on the basis of the discovery of a scientific diet law.

Studies shows that the traditional concept "eating well at breakfast, full at lunch, little at dinner" is not a quite scientific concept. Following this diet habit, excessive intake of food at noon either disturbs the release of the stored energy, or expend much dynamic energy. After the massive intake, 30~70% energy is committed to the gastric-intestinal digestion, which makes people feel sleepy. Another problem is that the accumulations of energy along with new nutritional intake may cause the energy statically storing, which easily results in obesity.

Based upon the law of human body's biological clock and the law of ingesting full nutrition, a new concept as "eat well at the breakfast, little at lunch, full at dinner" is put forward. With this knowledge and on the basis of the new life-science theory, we has developed a series 21 century food ---- MEBO powder range with high efficiency, high energy and full nutrition. Combined with the traditional concept of "balanced diets integrating grains, fruits, meats and vegetables", the products were prepared on the basis of the advanced qualitative and quantitative analysis of nutriology. Made from purely natural food, they contain a mixture of coarse and refined grain, a combination of botanical and animal proteins, the ester of middle-chain in plants to provide high energy, vegetables, flavoring to make flavours and colorful, supplement of vitamins and trace elements, and proper fiber to adjust digestive function. The high-technology and value-added products are the Group's new contributions for the health of human being.

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