It has been well established that vertebrates of lower species, particularly urodele amphibians (common called “salamanders”), have an intrinsic capacity to regenerate a variety of body parts, including limbs, tail, jaw, and retina. In higher mammals, examples of complex tissue regeneration are less common but can be seen in the seasonal regrowth of deer antlers. For humans, there is description of distal fingertip regeneration in children, but not in fully developed adults. Thus, some concluded that regenerative potential declines with the evolution of complexity. See review by Gurtner GC et al. (2007) Annu. Rev. Med. 58:299-312.

For an adult with a severed distal finger, the convention treatment generally includes surgical debridement of damaged tissue and suture of the residual tissues with the severed fingertip (if it can be retrieved) or direct closure of the wound (if the fingertip cannot be found or salvageable) to form a stump. Thus, this approach not only leads to scarring of the hand, but also results in reduction deformity and, more importantly, loss of physiological function of the finger.

The invention of MEBO's regenerative therapy completely changes such a grim picture and represents a major paradigm shift in this field. Consistent with the regeneration of functional skin organ of an adult, application of MEBO's regenerative therapy to human adult limb regeneration has produced groundbreaking clinical r esults. The clinical evidence collected from near a thousand cases shows that after treated with the MEBO regenerative therapy adult patients with severely damaged or lost limbs can recover with fingertips regenerated with normal physiological structure and function. Click here for a slideshow of the clinical evidence.

As exemplified in the slideshow, application of MEBO's regenerative therapy to the treatment of lost or severely damaged fingers of adult humans could not only repair the wounds but also regeneration of fingers with normal structure and function, including bones, muscles, nerves, blood vessels, connective tissue, finger nails and skin. These results demonstrate that the regenerative potential of adult humans is much stronger than previously expected. Consistent with what was observed for the regeneration of skin of burn patients, establishing an appropriate moist environment favoring regeneration and providing nutrients to the wound to stimulate and sustain the regeneration by cultivating stem cells in situ is the key to the success. This regenerative therapy has been used for the last decade in China and 20+ other countries for treating a wide variety of wound, including severely damaged or lost limb as exemplified herein.

In the spring of 2008 there were widely publicized news reports of a 69-year-old man named Lee Spievack in Cincinnati, Ohio, U.S., who regrew a fully functional digit after 3/8 in of his fingertip was accidentally severed by a model plane and couldn't be retrieved. See for example an Associated Press report at http://www.nydailynews.com/news/us_world/2008/04/30/2008-04-30_man_regrew_finger__with_pig_powder.html . According to the reports, after the accident, Spievack applied an extract of pig bladder to his wound, and within a month his fingertip grew back with tissue, nerves, skin, nail, and a fingerprint.

This story, although an isolated incident that needs to be validated clinically, further supports MEBO's belief that the human body, either of a child or an adult, possesses a strong intrinsic regenerative potential. The key question is how this regenerative potential can be harnessed to enable repair and regeneration of the body in the face of injury, diseases and aging.

MEBO provides the answer to this question by developing uniquely combined and formulated botanical products which have been mass produced and reliably used to treat millions of patients for the last two decades. The clinical evidence we obtained is not isolated and anecdotal, but results of decade-long practice of MEBO regenerative therapy invented by Dr. Rongxiang Xu. The fact that the severely injured or lost limbs of adults can be regenerated with restoration of structure and function by using the MEBO regenerative therapy sheds new light onto regenerative medicine and creates a revolutionary scientific field centered on regeneration of functional human organs via cultivating stem cells in situ and in vivo .